Estratest Drug Interactions

If you combine grapefruit juice, protease inhibitors, or thyroid medications with Estratest, drug interactions could occur. These interactions can decrease the effectiveness of the hormone medication or increase your risk for side effects. Other medicines that may lead to potentially negative Estratest drug interactions include certain antibiotics or antifungals, insulin, St. John's wort, cyclosporine, and barbiturates.

An Overview of Estratest Drug Interactions

Estratest® (esterified estrogens/methyltestosterone) can potentially interact with numerous other medicines. Some of the medicines that may lead to Estratest drug interactions include:
 
  • Barbiturate medications, including but not limited to:
 
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
  • Certain seizure medications, such as:
 
 
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • Grapefruit juice
  • Insulin
  • Protease inhibitors, such as:
 
 
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • St. John's wort (Hypericum perforatum)
  • Thyroid medications, including:
 
 
  • Various antibiotics or antifungals, including:
 
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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