Estraderm Drug Interactions

If you take protease inhibitor HIV medications or rifamycin antibiotics together with Estraderm, drug interactions could occur. Some drug interactions may decrease the effectiveness of the estrogen medicine, while others may increase your risk of developing side effects. Other medications that may lead to Estraderm interactions include St. John's wort, various antifungals or antibiotics, barbiturates, and thyroid replacement medicines.

 

An Introduction to Estraderm Drug Interactions

Estraderm® (estradiol patch) has the potential to interact with many other medications. Some of the medicines that may lead to Estraderm interactions include:
 
  • A few seizure medications, including:

 

 

  • Barbiturates, including (but not limited to):

 

    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
     
  • Protease inhibitor HIV medications, such as:

 

 

  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
     
  • St. John's wort (Hypericum perforatum), an herbal supplement
     
  • Thyroid replacement medications, including:

 

 

  • Various antifungal medications or antibiotics, such as:

 

    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®).

 

(Estraderm Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;