Estrace Drug Interactions

Make sure to talk to your healthcare provider about any other medications you are taking before using Estrace. Drug interactions may occur if Estrace is combined with certain medications, such as barbiturates, some seizure medications, and protease inhibitors. These drug interactions with Estrace may cause your body to metabolize the medications differently than intended, possibly increasing your risk of side effects or other problems.

 

An Introduction to Estrace Drug Interactions

Estrace® (estradiol) can potentially interact with various other medications. Some of the medicines that may lead to Estrace interactions include:
 
  • Barbiturates, including, but not limited to:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

  • Certain antifungal medications or antibiotics, such as:

 

    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)

 

  • Certain seizure medications, such as:

 

 

  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
     
  • Grapefruit juice
     
  • Hypothyroidism (underactive thyroid) medications, including:

 

 

  • Protease inhibitor HIV medications, such as:

 

 

  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
     
  • St. John's wort (Hypericum perforatum).
     
(Estrace Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;