Estrace Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
Estrace is combined with any of the drugs listed above.
Barbiturate Medications
Barbiturates may cause your body to metabolize the hormones in Estrace too rapidly, leading to low levels of Estrace in the body. This can make Estrace less effective, but it is not a serious drug interaction.
Certain Antifungals or Antibiotics
Some antibiotic or antifungal medications may decrease the ability of your liver to metabolize Estrace, leading to high levels of Estrace in the body. This may increase the risk of
Estrace side effects. Check with your healthcare provider before combining Estrace with certain antibiotics or antifungals.
Certain Seizure Medications
Some
seizure medications may cause your body to metabolize the hormones in Estrace too quickly, leading to low levels of Estrace in the body. Although this can make Estrace less effective, it is not a dangerous drug interaction.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Estrace may increase the level of cyclosporine in your blood, increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many
Estrace alternatives.
Grapefruit Juice
Grapefruit juice may decrease the ability of your liver to metabolize Estrace, leading to high levels of Estrace in the body. This may increase the risk of Estrace side effects.
Hypothyroidism Medications
If you take medications for an underactive thyroid (hypothyroidism) and Estrace together, your healthcare provider may need to increase the dose of your thyroid medication. Your healthcare provider should monitor you and make any necessary adjustments.
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