Estrace Vaginal Cream Warnings and Precautions

To help ensure safe and effective treatment with Estrace Vaginal Cream, warnings and precautions for the medication should be reviewed beforehand. Before using the product, let your healthcare provider know if you have high cholesterol, heart disease, or diabetes. You should not use Estrace Vaginal Cream if you have liver disease, have ever had a blood clot, or have a history of breast cancer.

 

Estrace Vaginal Cream: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Estrace® Vaginal Cream (estradiol vaginal cream) if you have:
 
  • Cancer (or if you have had cancer in the past)
  • Unexplained vaginal bleeding
  • High blood pressure (hypertension)
  • High cholesterol
  • Had a blood clot
  • Had a heart attack or stroke
  • Heart disease
  • Liver disease, such as liver failure, cirrhosis, hepatitis, or liver tumors
  • Kidney disease, including kidney failure (renal failure)
  • Diabetes
  • Had yellowing of the whites of the eyes or skin (jaundice) during a prior pregnancy or estrogen use
  • Gallbladder disease
  • Congestive heart failure (CHF)
  • An underactive thyroid (hypothyroidism)
  • Low calcium levels in the blood (hypocalcemia)
  • Endometriosis
  • Any allergies, including allergies to drugs, foods, preservatives, or dyes.
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Also, let your healthcare provider know if you:
 
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Have an upcoming surgery
  • Smoke cigarettes.
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Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Estrace Vaginal Cream Warnings and Precautions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;