Estrace Vaginal Cream Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
Estrace Vaginal Cream is combined with any of the drugs listed above.
Barbiturate Medications
Barbiturates may cause your liver to metabolize the hormones in
Estrace Vaginal Cream too quickly, leading to low levels of Estrace Vaginal Cream in the body. Because Estrace Vaginal Cream acts directly on the vaginal tissues and is absorbed into the bloodstream without passing through the liver first (which happens with oral medications), this interaction is probably not significant.
Certain Antibiotics or Antifungals
Some antibiotic or antifungal medications may decrease the ability of your liver to metabolize Estrace Vaginal Cream, leading to high levels of Estrace Vaginal Cream in the body. This may increase the risk of
Estrace Vaginal Cream side effects. Check with your healthcare provider before combining Estrace Vaginal Cream with certain antibiotics or antifungals.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Estrace Vaginal Cream may increase the level of cyclosporine in your blood, increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many Estrace Vaginal Cream alternatives.
Grapefruit Juice
Grapefruit juice may decrease the ability of your body to metabolize Estrace Vaginal Cream, leading to high levels of Estrace Vaginal Cream in the body. This may increase the risk of Estrace Vaginal Cream side effects.
Protease Inhibitors
Protease inhibitors may decrease the ability of your liver to metabolize Estrace Vaginal Cream, leading to high levels of Estrace Vaginal Cream in the body. This may increase the risk of Estrace Vaginal Cream side effects. Check with your healthcare provider before combining Estrace Vaginal Cream with a protease inhibitor.
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