Divigel Warnings and Precautions

You should let your healthcare provider know if you have endometriosis, diabetes, or asthma before taking Divigel. Warnings and precautions for the medication should also be discussed with your healthcare provider, as Divigel could cause certain side effects or complications. You should not be taking Divigel if you have liver disease, are pregnant, or have a history of breast cancer.

 

Divigel: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Divigel® (estradiol gel) if you have:
 
  • Unexplained vaginal bleeding
  • Had a heart attack or stroke
  • Had a blood clot
  • High blood pressure (hypertension)
  • Heart disease or heart problems of any kind
  • Cancer (or if you have had cancer in the past)
  • Diabetes
  • Had yellowing of the whites of the eyes or skin (jaundice) during a prior pregnancy or estrogen use
  • Systemic lupus erythematosus (SLE or lupus)
  • Asthma
  • Porphyria (a condition involving problems with certain enzymes in the body)
  • Seizures or epilepsy
  • Kidney disease, including kidney failure (renal failure)
  • Gallbladder disease
  • High cholesterol or high triglycerides
  • Migraines
  • Hepatic hemangioma (a kind of liver tumor)
  • Liver disease, such as liver failure, cirrhosis, hepatitis, or liver tumors
  • An underactive thyroid (hypothyroidism)
  • Endometriosis
  • Any allergies, including allergies to drugs, foods, preservatives, or dyes.
     
Also, let your healthcare provider know if you:
 
  • Smoke cigarettes
  • Have an upcoming surgery
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
     
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Divigel Warnings and Precautions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;