A safe and effective DIM dosage has not been established at this time. Since very little information is available to help determine an appropriate dosage, it is probably best to follow the recommendations on the label of your particular product. It is important to understand that these DIM dosing guidelines may not have much scientific basis.
DIM (diindolylmethane) is a dietary supplement taken for cancer prevention and various other uses. Unlike medications (for which the standard doses have been well established in carefully designed studies), there is less information for determining the best dose for herbal supplements, including DIM.
With prescription (and non-prescription) medications, researchers establish the most effective and safe doses in special studies, known as dose-range studies. These studies are done early in the development of medications, long before they are ever approved. However, because dietary supplements do not require approval, dose-range studies are rarely performed. Without such studies, only vague "trial and error" information is available.
At this time, there is not enough information available to recommend a safe and effective dose of DIM for any use. With so little information to guide you in determining an appropriate dose for DIM, it is reasonable to follow the dosing instructions provided with your particular product (with an understanding that such recommendations probably have very little scientific basis).
Some considerations for people taking DIM include:
- Since the manufacturing of supplements (such as DIM) is not closely regulated, it is important to choose a trustworthy manufacturer for DIM supplements. Your pharmacist can help you find a DIM supplement from a good manufacturer.
- If you have any chronic health problems or take any prescription medications, it is probably a good idea to check with your healthcare provider before taking DIM.
- If you are unsure about anything related to your dose of DIM (or DIM dosing in general), please talk with your healthcare provider.