Depo-Estradiol

Depo-Estradiol is an estrogen medication used to relieve menopausal symptoms and to replace hormones in younger women whose ovaries do not produce enough estrogen. This prescription medication works by replacing the estrogen that the ovaries no longer produce. Depo-Estradiol is injected into a muscle every three to four weeks. Although most women tolerate the medication well, side effects can include headaches, nausea, and breast pain.

Depo-Estradiol Drug Information

What Is Depo-Estradiol?

Depo^®-Estradiol (estradiol cypionate) is a prescription hormone replacement medication that contains estrogen. It comes as a long-acting injection that is injected into a muscle every three to four weeks. Depo-Estradiol is approved for the following uses:

Treating menopausal symptoms, such as hot flashes or night sweats
Replacing hormones in younger women whose ovaries do not produce enough estrogen (or who have had their ovaries removed).

(Click Depo-Estradiol Uses for more information on what Depo-Estradiol is used for, including possible off-label uses.)

Who Makes Depo-Estradiol?

Depo-Estradiol is made by Pfizer, Inc.

How Does Depo-Estradiol Work?

Depo-Estradiol contains estradiol, a hormone that is the predominant estrogen in premenopausal women. Depo-Estradiol helps to relieve menopausal symptoms by replacing the estrogen that the ovaries no longer produce.

Depo-Estradiol is formulated in oil to make the injection long-acting.

When and How to Use Depo-Estradiol

Some general considerations for when and how to use Depo-Estradiol include the following:

Depo-Estradiol is injected into a muscle every three to four weeks.
Usually, your healthcare provider will inject Depo-Estradiol for you.
For the medication to work properly, it must be taken as prescribed.

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