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Depo-Estradiol Warnings and Precautions
There are several possible risks that you should be aware of before starting Depo-Estradiol. Warnings and precautions for this medication include potential drug interactions, an increased risk of strokes or blood clots, and possible allergic reactions. Also, make sure your healthcare provider is aware of any other medical conditions you may have, as Depo-Estradiol can make certain conditions worse (such as endometriosis, diabetes, and asthma).
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You should talk with your healthcare provider prior to using Depo®-Estradiol (estradiol cypionate) if you have:
- Heart disease or heart problems of any kind
- Cancer (or a history of cancer) of any kind
- Had a heart attack, blood clot, or stroke
- Unexplained abnormal vaginal bleeding
- High blood pressure, high cholesterol, or high triglycerides
- Gallbladder disease
- Diabetes
- Liver disease, such as liver failure, cirrhosis, hepatitis, or liver tumors
- Asthma
- Porphyria (a condition involving problems with certain enzymes in the body)
- Seizures or epilepsy
- Had yellowing of the whites of the eyes or skin (jaundice) during a prior pregnancy or estrogen use
- Systemic lupus erythematosus (SLE, or lupus)
- Migraine headaches
- Hepatic hemangioma (a kind of liver tumor)
- Kidney disease, including kidney failure (renal failure)
- An underactive thyroid (hypothyroidism)
- Endometriosis
- Any allergies, including allergies to drugs, foods, preservatives, or dyes.
Also, let your healthcare provider know if you:
- Are pregnant or thinking of becoming pregnant
- Are breastfeeding
- Have an upcoming surgery
- Smoke cigarettes.
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD