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Covaryx Warnings and Precautions
To help minimize risks while using Covaryx, warnings and precautions for the medicine should be discussed with your healthcare provider before starting treatment. Tell your healthcare provider about all other medications you are taking to help prevent drug interactions and any medical conditions you have, including diabetes, endometriosis, or hypertension. Precautions and warnings with Covaryx also apply to women who have liver dysfunction or gallbladder disease.
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You should talk with your healthcare provider prior to using Covaryx™ (esterified estrogens/methyltestosterone) if you have:
- Cancer (or if you have had cancer in the past)
- Unexplained vaginal bleeding
- A history of heart attack or stroke
- Heart problems of any kind
- A history of blood clots
- High blood pressure (hypertension), high triglycerides, or high cholesterol
- Diabetes
- Gallbladder disease
- Liver disease, such as liver failure, cirrhosis, hepatitis, or liver tumors
- Kidney disease, including kidney failure (renal failure)
- An underactive thyroid (hypothyroidism)
- Yellowing of the whites of the eyes or skin (jaundice) during a prior pregnancy or estrogen use
- Low calcium levels in the blood (hypocalcemia)
- Endometriosis
- Any allergies, including allergies to drugs, foods, preservatives, or dyes.
Also, let your healthcare provider know if you:
- Have an upcoming surgery
- Smoke cigarettes
- Are pregnant or thinking of becoming pregnant
- Are breastfeeding.
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD



