Cenestin Drug Interactions

Prior to taking Cenestin, make sure your healthcare provider is aware of any other medications you are taking to avoid possible drug interactions. Cenestin can cause negative interactions with many medications, such as certain seizure medications, cyclosporine, and several antibiotics. Some of these drug interactions with Cenestin can affect the way your body metabolizes these medicines, possibly increasing your risk of side effects or decreasing the effectiveness of the medications.

 

An Introduction to Cenestin Drug Interactions

Cenestin® (conjugated estrogens) can potentially interact with numerous other medicines. Some of the medicines that may lead to Cenestin interactions include:
 
  • Barbiturate medications, including, but not limited to:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

  • Certain seizure medications, such as:

 

 

  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
     
  • Grapefruit juice
     
  • Protease inhibitors, such as:

 

 

  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
     
  • St. John's wort (Hypericum perforatum)
     
  • Thyroid medications, including:

 

 

  • Various antibiotics or antifungals, including:

 

    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®).

 

(Cenestin Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;