Brisdelle is currently the only non-hormonal treatment approved for reducing hot flashes from menopause. Other medicines approved for the treatment of hot flashes contain the hormone estrogen alone or a combination of estrogen with progestin (see Hormone Replacement Therapy for information about hormonal treatment for hot flashes). Such medications may include but are not limited to:
- Conjugated estrogens
- Estradiol cypionate (Depo®-Estradiol)
- Estradiol valerate (Delestrogen®)
- Estropipate (Ogen®)
- Conjugated estrogens/medroxyprogesterone (Prempro®).
In addition, several other non-hormonal medications, though not FDA-approved to treat hot flashes, are sometimes used "off-label" for this reason. Examples of these medications include:
- Clonidine hydrochloride (Catapres®, Catapres-TTS®, Duraclon®, Kapvay™, Nexiclon® XR)
- Gabapentin (Neurontin®)
- Other SSRI or SNRI medications, such as:
- Complementary and alternative treatments, such as black cohosh and soy.
Some women also find that a variety of coping strategies or lifestyle changes can help them get through hot flashes. Examples of some of the strategies you can try include:
- Keeping track of when hot flashes occur, so you can identify and avoid things that trigger your hot flashes
- Moving to a cool area when a hot flash starts
- Sleeping with a fan on if hot flashes occur at night
- Drinking a cool liquid when a hot flash starts
- Losing weight (if you are overweight).