Brisdelle Drug Interactions

Brisdelle Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Brisdelle is combined with any of the drugs listed above.
 
Atomoxetine
Brisdelle can increase blood levels of atomoxetine, potentially increasing your risk for atomoxetine side effects. Your healthcare provider may choose to give you a lower atomoxetine dose if you take these medications together.
 
Certain Arrhythmia Medicines
Taking Brisdelle with certain arrhythmia medications can increase the level of the arrhythmia medication in your blood, potentially increasing your risk of side effects. Some arrhythmia medicines can also increase blood levels of Brisdelle. Your healthcare provider may need to monitor you more closely if you take these medicines together.  
 
Cimetidine
Cimetidine can increase the level of Brisdelle in your blood, potentially increasing your risk for side effects. Your healthcare provider may need to monitor you more closely if you take these medicines together.
 
Digoxin
Taking Brisdelle and digoxin together may decrease the level of digoxin in your blood. If you take these medications together, your healthcare provider may need to monitor your digoxin blood levels, and adjust your dose if needed.
 
Diuretics
Brisdelle can cause low blood sodium levels (known medically as hyponatremia). Taking it with a diuretic may increase your risk for this side effect. Talk to your healthcare provider before taking these medications together.
 
Fosamprenavir
Fosamprenavir may decrease the level of Brisdelle in your blood, potentially making it less effective. Your healthcare provider may need to monitor you more closely if you take these medicines together.
 
Medications That Thin the Blood
Taking Brisdelle with medications that increase the risk for bleeding can further increase your risk for dangerous internal bleeding. Talk to your healthcare provider before taking these medications together. Contact your healthcare provider if you develop any signs of bleeding while taking Brisdelle, such as:
 
  • Weakness
  • Abdominal (stomach) pain
  • Black, tarry stools
  • Vomit that looks like coffee grounds.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking an MAOI with Brisdelle can cause a life-threatening side effect known as serotonin syndrome. Serotonin syndrome can lead to a variety of serious symptoms, such as agitation, hallucinations, a fast heartbeat, sweating, muscle spasms, and seizures (see Brisdelle Warnings and Precautions for more symptoms of serotonin syndrome). You should not take Brisdelle and an MAOI together, or within 14 days of one another.
 
Other Forms of Paroxetine
Brisdelle contains the active ingredient paroxetine, and should not be taken with other medications that contain paroxetine. Taking these medicines together could lead to a paroxetine overdose and potentially serious side effects.
 
Other Medications That Affect Serotonin
Taking Brisdelle with other medications that increase serotonin levels could cause a rare but life-threatening reaction known as serotonin syndrome. Serotonin syndrome can lead to a variety of serious symptoms, such as headaches, nausea, sweating, and dizziness (see Brisdelle Warnings and Precautions for more symptoms of serotonin syndrome). Talk to your healthcare provider before taking these medications together. In many cases, such combinations may still be recommended, although with more careful monitoring.
 
Phenobarbital
Phenobarbital may decrease blood levels of Brisdelle, potentially making it less effective. Your healthcare provider may need to monitor you more closely if you take these medicines together.
 
Phenothiazine
Brisdelle can increase blood levels of phenothiazines, potentially increasing your risk for side effects. Your healthcare provider may need to monitor you more closely if you take these medicines together. It is recommended that Brisdelle not be taken in combination with phenothiazine thioridazine.
 
Phenytoin
Phenytoin may decrease blood levels of Brisdelle, potentially making it less effective. Your healthcare provider may need to monitor you more closely if you take these medicines together.
 
Pimozide
Taking pimozide with Brisdelle could increase blood levels of pimozide and cause a dangerous irregular heart rhythm (arrhythmia) called QT prolongation. In general, these medicines should not be taken together.
 
Risperidone
Brisdelle can increase the level of risperidone in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to decrease your risperidone dose if you take these medicines together.
 
Ritonavir
Ritonavir may decrease the level of Brisdelle in your blood, potentially making it less effective. Your healthcare provider may need to monitor you more closely if you take these medicines together.
 
Tamoxifen
Brisdelle may decrease blood levels of tamoxifen, which could make it less effective. Talk to your healthcare provider about this potential interaction before taking these medicines together.
 
Theophylline
Brisdelle can increase the level of theophylline in your blood, potentially increasing your risk for side effects. Your healthcare provider may need to decrease your theophylline dose if you take these medicines together.
 
Tricyclic Antidepressants
Taking Brisdelle with a tricyclic antidepressant can increase the level of the tricyclic antidepressant in your blood. Your healthcare provider may need to reduce your tricyclic antidepressant dose if you take these medicines together.
 
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Brisdelle Medication Information

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