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Activella Warnings and Precautions
Women with medical conditions such as heart disease, high blood pressure, or congestive heart failure should consult their healthcare provider before taking Activella. Warnings and precautions for this medication also include watching out for potential drug interactions and screening for breast cancer regularly. Activella may increase the risk of breast cancer, as well as other problems, including dementia, fluid retention, and gallbladder disease.
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Talk with your healthcare provider prior to using Activella® (estradiol/norethindrone) if you have:
- A history of heart attack or stroke
- Heart disease
- A history of blood clots
- Cancer (or if you have had cancer in the past)
- High blood pressure (hypertension)
- Congestive heart failure (CHF)
- Diabetes
- Yellowing of the whites of the eyes or skin (jaundice) during a prior pregnancy or estrogen use
- Gallbladder disease
- High cholesterol or high triglycerides
- Liver disease, such as liver failure, cirrhosis, hepatitis, or liver tumors
- Systemic lupus erythematosus (SLE or lupus)
- Asthma
- Porphyria (a condition involving problems with certain enzymes in the body)
- Seizures or epilepsy
- Migraines
- Hepatic hemangioma (a kind of liver tumor)
- Kidney disease, including kidney failure (renal failure)
- An underactive thyroid (hypothyroidism)
- Endometriosis
- Unexplained vaginal bleeding
- Any allergies, including allergies to drugs, foods, preservatives, or dyes.
Also, let your healthcare provider know if you:
- Have an upcoming surgery
- Smoke cigarettes
- Are pregnant or thinking of becoming pregnant
- Are breastfeeding.
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD