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Activella Drug Interactions
Certain substances can interact negatively with Activella. Drug interactions may occur if Activella is taken with rifamycin antibiotics, protease inhibitors, thyroid medications, and various antibiotics or antifungals. Drug interactions with Activella could increase the level of the medications in your blood, which can increase your risk for developing side effects or reduce the effectiveness of the medicines.
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Activella® (estradiol/norethindrone) can potentially interact with several other medications and substances. Some of the things that may lead to Activella drug interactions include:
- Barbiturates, such as:
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Grapefruit juice
- Protease inhibitors, such as:
- Amprenavir (Agenerase®)
- Atazanavir (Reyataz®)
- Fosamprenavir (Lexiva®)
- Indinavir (Crixivan®)
- Nelfinavir (Viracept®)
- Ritonavir (Norvir®)
- Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
- Some seizure medications, such as:
- Carbamazepine (Carbatrol®, Epitol®, Equetro™, Tegretol®)
- Oxcarbazepine (Trileptal®)
- Phenytoin (Dilantin®, Phenytek®)
- St. John's wort (Hypericum perforatum)
- Thyroid medications (for treating hypothyroidism), such as:
- Liothyronine (Cytomel®)
- Liotrix (Thyrolar®)
- Levothyroxine (Levothroid®, Levoxyl®, Synthroid®, Tirosint®, Unithroid®)
- Thyroid (Armor® Thyroid, Nature-Throid®)
- Various antibiotics or antifungals, such as:
- Clarithromycin (Biaxin®)
- Erythromycin (Ery-Tab®)
- Isoniazid (Nydrazid®)
- Itraconazole (Sporanox®)
- Ketoconazole (Nizoral®)
- Miconazole
- Telithromycin (Ketek®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD