Drugs That Interfere With Activella

Activella Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Activella is combined with any of the drugs listed above.
 
Barbiturates
Barbiturates may cause your body to metabolize the hormones in Activella too quickly, possibly leading to low levels of Activella in the body. Although this can make Activella less effective, it is not a serious drug interaction.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Estrogen and progestin hormones (such as the ones in Activella) may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many Activella alternatives.
 
Grapefruit Juice
Grapefruit juice may decrease the ability of your liver to metabolize Activella, possibly leading to high levels of Activella in the body. This may increase the risk of Activella side effects.
 
Protease Inhibitors
Protease inhibitors may decrease the ability of your liver to metabolize Activella, potentially leading to high levels of Activella in the body. This may increase the risk of Activella side effects. Check with your healthcare provider before combining these two medications.
 
Rifamycin Antibiotics
Rifamycin antibiotics may cause your body to metabolize the hormones in Activella too quickly, possibly leading to low levels of Activella in the body. Although this can make Activella less effective, it is not a dangerous drug interaction.
 
Some Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in Activella too quickly, possibly leading to low levels of Activella in the body. Although this can increase the risk of spotting or bleeding and make Activella less effective, it is not a dangerous drug interaction.
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